The rationale of the present study was to formulate, characterize and evaluate the polymeric nanoparticle of rosuvastatin calcium, a poorly water-soluble and low bioavailable drug with the intend of recuperating aqueous solubility consequently the dissolution rate. Rosuvastatin calcium (ROSCa) biodegradable polymeric nanoparticles were prepared by ionotropic gelation technique. Material and polymer used in the preparation of biodegradable polymeric nanoparticles were tween 80 %, chitosan (CH) and sodium tripolyphosphate (STPP). Different ratios of polymers were used in the formulation of rosuvastatin calcium formulations (RF1 to RF9). The prepared nanoparticles were characterized by drug-excipient interactions Fourier-transform infrared spectroscopy (FTIR) and evaluated for percent drug content uniformity, particle size, zeta potential, % entrapment efficacy, in-vitro drug release and short-term stability. RF4 formulation exhibited 88.49 % of drug released within 10 hrs and exhibited Korsmeyer Peppas drug release kinetics. Stability studies indicated RF4 formulation exhibited better stability.
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